Monday, November 29, 2004
Cocoa, Flavanols and Cardiovascular Risk
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Cocoa, Flavanols and Cardiovascular Risk:
""The Kuna Indians in Panama, living in their indigenous island home in the Caribbean, do not show the typical rise in blood pressure with age, and hypertension is very rare.[34] In a study that began with the search for protective genes, the observation that migration to Panama City led to a loss of the protection against hypertension made it clear that an environmental factor was involved. Examination of their diet uncovered the fact that they drank large volumes of a flavanol-rich cocoa.[2] Subsequent in vitro studies suggesting that cocoa extracts can induce endothelium-dependent relaxation[4] led to studies in healthy volunteers,[9] and in patients with vascular risk or disease.[1] In the studies of Heiss et al. ingestion of flavanol-rich cocoa led to an increase in flow-mediated vasodilation of the brachial artery following five minutes of ischaemia, a response that correlated with biochemical evidence of increased nitric oxide bioavailability.[8] In the normal volunteers studied by Fisher et al. flavanol-rich cocoa induced striking dilatation of the vessels of the finger, which was reversed completely by an arginine analogue that blocks nitric oxide synthesis (figure 1).[9]""
and
""Endothelial dysfunction with a consequent reduction in nitric oxide production has achieved a central conceptual role in the pathogenesis of atherosclerosis and coronary artery disease, diabetes mellitus and hypertension. Recent evidence that flavanol-rich cocoa activates vascular nitric oxide synthesis in the intact human raises an interesting possibility of a therapeutic potential.""
Potentially very good news for Hershey foods, what, what?
[Via Medscape Headlines]
Friday, November 26, 2004
Common Good Promoting Special Health Courts
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Common Good is planning a brochure for mass distribution to 'advance the concept of a special health court.' I've written about this organization before. Their proposal, which has some pretty big names behind it, calls for the creation of special health courts. Some of the details include:
- Full-time judges
- Neutral experts
- Speedy processing at lower cost
- Schedule for non-economic damages
- Liberalized standard for patient recovery
Common Good is accepting donations (tax deductible) to help with the mass distribution of their brochures.
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Tuesday, November 23, 2004
New Female Sterilization Technique Quicker, Easier and Cheaper
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New Female Sterilization Technique Quicker, Easier and Cheaper:
""Mayo Clinic gynecologists have discovered that hysteroscopic sterilization, a new method of plugging the fallopian tubes to prevent conception, will save patients money compared to laparoscopic tubal ligation, the most commonly used method of sterilization for women. This technique involves inserting a nickel-titanium and stainless steel springlike device into the fallopian tubes using a hysteroscope, a tiny, fiberoptic camera. The metal device encapsulates and holds in place white polyester fibers able to cause scarring and thus block the fallopian tubes within 12 weeks, preventing the possibility of future pregnancy.""
Of course, it's still not as easy as a man having a vasectomy, but this technique would not require laparoscopy and would thus be safer for the woman.
[Via Science Blog - Science News Stories]
Tuesday, November 16, 2004
"I'd rather be judged by 12 than carried by 6"
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Here's a Seal's perspective on all the attention being paid to the issue of a Marine supposedly shooting a wounded terrorist in Fallujah:
""Here is your situation Marine. You just took fire from unlawful combatants shooting from a religious building attempting to use the sanctuary status of their position as protection. But you're in Fallujah now, and the Marine Corps has decided that they're not playing that game this time. That was Najaf. So you set the mosque on fire and you hose down the terrorists with small arms, launch some AT-4s (Rockets), some 40MM grenades into the building and things quiet down. So you run over there, and find some tangos wounded and pretending to be dead. You are aware that suicide martyrdom is like really popular with these kind of idiots, and like taking some Marines with them would be really cool. So you can either risk your life and your fireteam's lives by having them cover you while you bend down and search a guy that you think is pretending to be dead for some reason. Also, you don't know who or what is in the next room, and you're already speaking english to each other and its loud because your hearing is poor from shooting people for several days. So you know that there are many other rooms to enter, and that if anyone is still alive in those rooms, they know that Americans are in the mosque. Meanwhile (3 seconds later), you still have this terrorist that was just shooting at you from a mosque playing possum. What do you do?
You double tap his head, and you go to the next room, that's what."
Sunday, November 14, 2004
45,800,000 American Adults (Still!) Smoke
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""In 2002, a total of 45,800,000 US adults (22.5%) were current smokers, a decrease from 24.1% in 1998, and an estimated 46 million adults were former smokers (1). For the first time, more adults had quit smoking than were still smoking""
Many more details in the MMWR Report: Great American Smokeout --- November 18, 2004
[Via Medical News Today]
Vioxx Non-Cox2 Effect Demonstrated
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It's worth pointing out that discussion of a drugs action typically focus on one known effect. That there may be others and that those can be harmful is amply demonstrated by the Vioxx example. An article just published in the journal 'Atherosclerosis' may explain what the second effect is in the case of Vioxx:
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs
Bottom line: "Abnormal changes in the structure or shape of lipids caused by Vioxx, especially in LDL, may explain why they are more susceptible to oxidative damage, and therefore, contribute to cardiovascular damage. Similar effects on susceptibility of lipids to oxidative damage have been observed with cigarette smoking, diabetes and in patients who have had a recent heart attack."
[Via Medical News Today]
Thursday, November 11, 2004
Veteran's Day
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It's Veteran's Day. Allow me to point you to a moving tribute to America's fighting men and women: http://www.clermontyellowribbon.com/untilthenflash.htm
Wednesday, November 10, 2004
Many People Won't Do What They're Told
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The New York Academy of Medicine: News & Publications: Terrorism Response Plans Will Not Protect Many Americans, New Academy Study Finds:
""Called Redefining Readiness: Terrorism Planning Through the Eyes of the Public and funded by the W. K. Kellogg Foundation, this year-long study gave the American people their first opportunity to describe how they would react to two kinds of terrorist attacks: a smallpox outbreak and a dirty bomb explosion. The rigorous study involved in-depth conversations with government and private-sector planners, 14 group discussions with diverse community residents around the country, and a telephone survey of 2,545 randomly selected adults in the continental United States. ""
Bottom Line: only about 40% would actually do as they are told and go to a smallpox vaccination center for fear of a) catching the illness form the crowds there and b) concern over side effects. The public would do worse in dealing with a dirty-bomb (radiation) attack.
[Via The Atlantic Monthly]
Tuesday, November 9, 2004
Obesity Triples Prescription Drug Costs
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FOXNews.com - Health - Obesity Triples Prescription Drug Costs:
""For normal-weight men, monthly prescription drug costs for heart disease-related drugs were $9.89 and for other drugs, $12.96. For overweight men, monthly prescription drug costs for heart disease-related drugs were $18.41 and for other drugs, $20.86. For obese men, monthly prescription drug costs for heart disease-related drugs were $42.02 and for other drugs, $38.29.""
Data apparently presented during an ongoing AHA meeting.
Saturday, November 6, 2004
Cold-Eeze Lawsuit Over Anosmia
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Colde-Eze subject of lawsuit for allegedly ruining the sense of smell. Recall I've posted about how well I think Cold-Eeze works. I guess I'll stick to the lozenges...
[Via medpundit]
Friday, November 5, 2004
Americans flock to Canada's immigration Web site
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From Reuter's News Agency:
":The number of U.S. citizens visiting Canada's main immigration Web site has shot up six-fold as Americans flirt with the idea of abandoning their homeland after President George W. Bush's election win this week.
"When we looked at the first day after the election, November 3, our Web site hit a new high, almost double the previous record high," immigration ministry spokeswoman Maria Iadinardi said on Friday.
On an average day some 20,000 people in the United States log onto the Web site, www.cic.gc.ca -- a figure which rocketed to 115,016 on Wednesday. The number of U.S. visits settled down to 65,803 on Thursday, still well above the norm.
Bush's victory sparked speculation that disconsolate Democrats and others might decide to start a new life in Canada, a land that tilts more to the left than the United States.""
[Via Drudge]
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Oct Dec
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