Weathering the Influenza Vaccine Crisis
Posted by Clark Venable on 11/11/2004
NEJM: Weathering the Influenza Vaccine Crisis
""Influenza vaccine is especially vulnerable to interruptions in supply, because of the unique features of influenza-vaccine production. Unlike any other vaccine, influenza vaccine must be reformulated to keep pace with antigenic changes in the hemagglutinin and neuraminidase proteins of influenzaviruses — essentially necessitating the manufacture of a brand new product from scratch every year. The process is a long one, beginning with the identification of new antigenic variants in the autumn of the previous year and the selection of the strains for inclusion in the vaccine, and proceeding to the generation of appropriate reference reagents, the production and purification of the vaccine antigens, and packaging and distribution, all within a period of six to eight months.""
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