NEJM: The Origins of Pandemic Influenza--Lessons from the 1918 Virus
Posted by Clark Venable on 11/24/2005
The Origins of Pandemic Influenza--Lessons from the 1918 Virus [free full text]
"...monitoring of the sequences of viruses isolated in instances of bird-to-human transmission for genetic changes in key regions may enable us to track viruses years before they develop the capacity to replicate with high efficiency in humans. Knowledge of the genetic sequences of influenza viruses that predate the 1918 pandemic would be extremely helpful in determining the events that may lead to the adaptation of avian viruses to humans before the occurrence of pandemic influenza. We could then conduct worldwide surveillance for similar events involving contemporary avian viruses. "
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